Titanium nanotubes activate genes related to bone formation in vitro
Identifieur interne : 002F18 ( Main/Exploration ); précédent : 002F17; suivant : 002F19Titanium nanotubes activate genes related to bone formation in vitro
Auteurs : Alfonso Pozio [Italie] ; Annalisa Palmieri [Italie] ; Ambra Girardi [Italie] ; Francesca Cura [Italie] ; Francesco Carinci [Italie]Source :
- Dental Research Journal [ 1735-3327 ] ; 2012.
Abstract
Titanium is used worldwide to make osseointegrable devices, thanks to its favorable characteristics as mechanical proprieties and biocompatibility, demonstrated by
To investigate how titanium nanotubes stimulate osteoblasts differentiation and proliferation, some osteoblast genes (SP7, RUNX2, COL3A1, COL1A1, ALPL, SPP1 and FOSL1) were analyzed by quantitative Real Time RT- PCR.
After 15 days, osteoblasts cultivated on titanium naotube showed the up-regulation of bone related genes SP7, ENG, FOSL1 and SPP1 and the down-regulation of RUNX2, COL3A1, COL1A1, and ALPL. After 30 days of treatment, the bone related genes SP7, ENG, FOSL1 and RUNX2 were up-regulated while COL3A1, COL1A1, ALPL and SPP1 were down-regulated.
Our results, demonstrates that titanium nanotubes can lead to osteoblast differentiation and extracellular matrix deposition and mineralization in dental pulp stem cells by the activation of osteoblast related genes SPP1, FOSL1 and RUNX2.
Url:
DOI: 10.4103/1735-3327.109736
PubMed: 23814577
PubMed Central: 3692167
Affiliations:
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Casaccia, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23814577</idno><idno type="pmc">3692167</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692167</idno><idno type="RBID">PMC:3692167</idno><idno type="doi">10.4103/1735-3327.109736</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002B73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B73</idno><idno type="wicri:Area/Pmc/Curation">002B73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B73</idno><idno type="wicri:Area/Pmc/Checkpoint">001C23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C23</idno><idno type="wicri:Area/Ncbi/Merge">004783</idno><idno type="wicri:Area/Ncbi/Curation">004783</idno><idno type="wicri:Area/Ncbi/Checkpoint">004783</idno><idno type="wicri:doubleKey">1735-3327:2012:Pozio A:titanium:nanotubes:activate</idno><idno type="wicri:Area/Main/Merge">002F33</idno><idno type="wicri:Area/Main/Curation">002F18</idno><idno type="wicri:Area/Main/Exploration">002F18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Titanium nanotubes activate genes related to bone formation <italic>in vitro</italic></title><author><name sortKey="Pozio, Alfonso" sort="Pozio, Alfonso" uniqKey="Pozio A" first="Alfonso" last="Pozio">Alfonso Pozio</name><affiliation wicri:level="3"><nlm:aff id="aff1">ENEA, IDROCOMB, C.R. Casaccia, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>ENEA, IDROCOMB, C.R. Casaccia, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Titanium is used worldwide to make osseointegrable devices, thanks to its favorable characteristics as mechanical proprieties and biocompatibility, demonstrated by <italic>in vivo</italic> studies with animal models and clinical trials over a forty-year period. However, the exact genetic effect of the titanium layer on cells is still not well characterized.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>To investigate how titanium nanotubes stimulate osteoblasts differentiation and proliferation, some osteoblast genes (SP7, RUNX2, COL3A1, COL1A1, ALPL, SPP1 and FOSL1) were analyzed by quantitative Real Time RT- PCR.</p></sec><sec id="st3"><title>Results:</title><p>After 15 days, osteoblasts cultivated on titanium naotube showed the up-regulation of bone related genes SP7, ENG, FOSL1 and SPP1 and the down-regulation of RUNX2, COL3A1, COL1A1, and ALPL. After 30 days of treatment, the bone related genes SP7, ENG, FOSL1 and RUNX2 were up-regulated while COL3A1, COL1A1, ALPL and SPP1 were down-regulated.</p></sec><sec id="st4"><title>Conclusions:</title><p>Our results, demonstrates that titanium nanotubes can lead to osteoblast differentiation and extracellular matrix deposition and mineralization in dental pulp stem cells by the activation of osteoblast related genes SPP1, FOSL1 and RUNX2.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pearce, Ai" uniqKey="Pearce A">AI Pearce</name></author><author><name sortKey="Richards, Rg" uniqKey="Richards R">RG Richards</name></author><author><name sortKey="Milz, S" uniqKey="Milz S">S Milz</name></author><author><name sortKey="Schneider, E" uniqKey="Schneider E">E Schneider</name></author><author><name sortKey="Pearce, Sg" uniqKey="Pearce S">SG Pearce</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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name="Italie"><region name="Latium"><name sortKey="Pozio, Alfonso" sort="Pozio, Alfonso" uniqKey="Pozio A" first="Alfonso" last="Pozio">Alfonso Pozio</name></region><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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